Journal article

Aminoglycoside use in paediatric febrile neutropenia - Outcomes from a nationwide prospective cohort study

Brendan J McMullan, Gabrielle M Haeusler, Lisa Hall, Louise Cooley, Andrew J Stewardson, Christopher C Blyth, Cheryl A Jones, Pamela Konecny, Franz E Babl, Francoise Mechinaud, Karin Thursky

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

Aminoglycosides are commonly prescribed to children with febrile neutropenia (FN) but their impact on clinical outcomes is uncertain and extent of guideline compliance is unknown. We aimed to review aminoglycoside prescription and additional antibiotic prescribing, guideline compliance and outcomes for children with FN. We analysed data from the Australian Predicting Infectious ComplicatioNs in Children with Cancer (PICNICC) prospective multicentre cohort study, in children <18 years with FN between November 2016 and January 2018. Impact of aminoglycoside use in the first 12 hours of FN on composite unfavourable outcome of death, ICU admission, relapse of infection or late-onset sepsis was a..

View full abstract