Multiple Sclerosis as a Syndrome-Implications for Future Management
Christopher M Dwyer, Linda Thien-Trang Nguyen, Luke M Healy, Ranjan Dutta, Samuel Ludwin, Jack Antel, Michele D Binder, Trevor J Kilpatrick
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2020
We propose that multiple sclerosis (MS) is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized. We describe several cellular mechanisms that could generate inflammatory demyelination through disruption of homeostatic interactions between immune and neural cells. We illustrate that genomics is important in identifying phenocopies, in particular for primary progressive MS. We posit that molecular profiling, rather than traditional clinical phenotyping, will facilitate meaningful patient stratification, as illustrated by interactions between HLA and a..View full abstract
This work was supported by MS Research Australia Post-Graduate Scholarship (to CD), Australian Government Research Training Program Scholarship (to LN), and National Health and Medical Research Council Investigator Grant (to TK). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.