Journal article

Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage

Sila Genc, Charles B Malpas, Alisha Gulenc, Emma Sciberras, Daryl Efron, Timothy J Silk, Marc L Seal

Developmental Cognitive Neuroscience | ELSEVIER SCI LTD | Published : 2020


The pubertal period involves dynamic white matter development. This period also corresponds with rapid gains in higher cognitive functions including attention, as well as increased risk of developing mental health difficulties. This longitudinal study comprised children aged 9-13 years (n = 130). Diffusion magnetic resonance imaging (dMRI) data were acquired (b = 2800s/mm2, 60 directions) at two time-points. We derived measures of fibre density and morphology using the fixel-based analysis framework and performed a tract-based mixed-effects modelling analysis to understand patterns of white matter development with respect to age, sex, pubertal stage, and the change in pubertal stage. We obse..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Career Development Award

Funding Acknowledgements

Data used in the preparation of this article were obtained from the NICAP study (National Health and Medical Research Council (NHMRC); project grant #1065895). The research and analyses were conducted within the Developmental Imaging research group, Murdoch Children's Research Institute, supported by the Victorian Government's Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation devoted to raising funds for research at The Royal Children's Hospital. SG was supported by an Australian Government Research Training Program (RTP) scholarship. ES was supported by an NHMRC Career Development Award (1110688).