Journal article

Dysfunctional coupling of the parahippocampal cortex and inferior frontal gyrus during memory suppression in posttraumatic stress disorder

Trevor Steward, Pritha Das, Gin S Malhi, Richard A Bryant, Kim L Felmingham

European Neuropsychopharmacology | ELSEVIER | Published : 2020


The current study aimed to identify alterations in brain activation and connectivity related to memory suppression in posttraumatic stress disorder (PTSD) using the Think/No-Think paradigm during functional magnetic resonance imaging (fMRI). Reduced activation in the parahippocampal cortex during No-Think vs. Baseline trials was found in participants with PTSD compared to controls with no history of trauma (pFWE<0.05). Trauma-related intrusive memories (r = 0.562, p = 0.046) and avoidance behaviors (r = 0.636, p = 0.020) were positively correlated with parahippocampal cortex activation during memory suppression in the PTSD group. Psychophysiological interactions (PPI) analysis identified inc..

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Awarded by Australian Research Council (ARC)

Awarded by NHMRC/MRFF Investigator Grant

Funding Acknowledgements

Funding for this study was provided by an Australian Research Council (ARC) Discovery Grant DP0881814; the ARC had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication. TS is supported by the University of Melbourne McKenzie Fellowship and a NHMRC/MRFF Investigator Grant (MRF1193736).