Dysfunctional coupling of the parahippocampal cortex and inferior frontal gyrus during memory suppression in posttraumatic stress disorder
Trevor Steward, Pritha Das, Gin S Malhi, Richard A Bryant, Kim L Felmingham
European Neuropsychopharmacology | ELSEVIER | Published : 2020
The current study aimed to identify alterations in brain activation and connectivity related to memory suppression in posttraumatic stress disorder (PTSD) using the Think/No-Think paradigm during functional magnetic resonance imaging (fMRI). Reduced activation in the parahippocampal cortex during No-Think vs. Baseline trials was found in participants with PTSD compared to controls with no history of trauma (pFWE<0.05). Trauma-related intrusive memories (r = 0.562, p = 0.046) and avoidance behaviors (r = 0.636, p = 0.020) were positively correlated with parahippocampal cortex activation during memory suppression in the PTSD group. Psychophysiological interactions (PPI) analysis identified inc..View full abstract
Awarded by Australian Research Council (ARC)
Awarded by NHMRC/MRFF Investigator Grant
Funding for this study was provided by an Australian Research Council (ARC) Discovery Grant DP0881814; the ARC had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication. TS is supported by the University of Melbourne McKenzie Fellowship and a NHMRC/MRFF Investigator Grant (MRF1193736).