Journal article

Gallium Fluoride Complexes with Acyclic Bispicolinic Ligands as Potential New Fluorine-18 Labelled Imaging Agents

HuiJing Koay, Mohammad B Haskali, Peter D Roselt, Jonathan M White, Paul S Donnelly

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | WILEY-V C H VERLAG GMBH | Published : 2020

Abstract

The positron-emitting radionuclide, fluorine-18, is used to radiolabel molecules to develop tracers for diagnostic imaging with positron-emission tomography. There is growing interest in the potential of using strong coordinate bonds between electropositive Ga(III) and electronegative fluoride (≈ 557 kJ/mol) to provide new methods of incorporating fluorine-18 into molecules. The potential of gallium(III) complexes with acyclic pentadentate bispicolinic acid containing ligands (H2L1–3) to form ternary complexes with fluoride, [GaL1–3F] was investigated with a view to developing new methods for fluorine-18 radiolabelling. A solid-phase peptide synthesis approach was used to produce a bispicoli..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

We would like to thank the Melbourne Mass Spectrometry and Proteomics Facility (MSPF) of The Bio21 Molecular Science and Biotechnology Institute at The University of Melbourne for the support of mass spectrometry analysis. Financial support from an Australian Research Council Linkage Grant (LP150100656) where the Industry Partner was Clarity Pharmaceuticals is acknowledged. Professor Rodney J. Hicks is acknowledged for his support of this research.