Trends in time to cancer diagnosis around the period of changing national guidance on referral of symptomatic patients: A serial cross-sectional study using UK electronic healthcare records from 2006-17
Sarah Price, Anne Spencer, Xiaohui Zhang, Susan Ball, Georgios Lyratzopoulos, Ruben Mujica-Mota, Sal Stapley, Obioha C Ukoumunne, Willie Hamilton
Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention | ELSEVIER SCI LTD | Published : 2020
BACKGROUND: UK primary-care referral guidance describes the signs, symptoms, and test results ("features") of undiagnosed cancer. Guidance revision in 2015 liberalised investigation by introducing more low-risk features. We studied adults with cancer whose features were in the 2005 guidance ("Old-NICE") or were introduced in the revision ("New-NICE"). We compared time to diagnosis between the groups, and its trend over 2006-2017. METHODS: Clinical Practice Research Datalink records were analysed for adults with incident myeloma, breast, bladder, colorectal, lung, oesophageal, ovarian, pancreatic, prostate, stomach or uterine cancers in 1/1/2006-31/12/2017. Cancer-specific features in the yea..View full abstract
Awarded by Cancer Research UK
Awarded by Cancer Research UK Advanced Clinician Scientist Fellowship Award
This study was funded by Cancer Research UK [C56843/A21550], who were not involved in any aspect of the conduct of the study, in writing the manuscript or in the decision to submit for publication. This research is also linked to the CanTest Collaborative, which is funded by Cancer Research UK [C8640/A23385], of which WH is co-Director, GL is Associate Director, AS is Senior Faculty, and SP is an affiliated Research Fellow.SB and OU were supported by the National Institute for Health Research (NIHR)Applied Research Collaboration (ARC) South West Peninsula. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. GL is supported by a Cancer Research UK Advanced Clinician Scientist Fellowship Award [C18081/A18180].