Journal article

A structural view of PA2G4 isoforms with opposing functions in cancer

Brendan W Stevenson, Michael A Gorman, Jessica Koach, Belamy B Cheung, Glenn M Marshall, Michael W Parker, Jessica K Holien

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2020

Abstract

The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has become apparent over the past 20 years. PA2G4 expression levels are correlated with prognosis in a range of human cancers, including neuroblastoma, cervical, brain, breast, prostate, pancreatic, hepatocellular, and other tumors. There are two PA2G4 isoforms, PA2G4-p42 and PA2G4-p48, and although both isoforms of PA2G4 regulate cellular growth and differentiation, these isoforms often have opposing roles depending on the context. Therefore, PA2G4 can function either as a contextual tumor suppressor or as an oncogene, depending on the tissue being studied. However, it ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Australia


Awarded by NHMRC


Awarded by Cancer Institute NSW Program


Awarded by Cancer Council NSW Program


Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Australia Project Grant GNT1125171, an SVI Top-up scholarship (to B. W. S.), an NHMRC Senior Principal Research Fellowship (to M. W. P.), a 5-Point Foundation Postdoctoral Fellowship (to J. K. H.), NHMRC Program Grant GNT1016699 (to G. M. M.), Cancer Institute NSW Program Grant 10/TPG/1-13 (to G. M. M.), Cancer Council NSW Program Grant PG-11-06 (to G. M. M.), and Neuroblastoma Australia (to G. M. M. and B. B. C.).