Journal article

Resistance to natural and synthetic gene drive systems

Tom AR Price, Nikolai Windbichler, Robert L Unckless, Andreas Sutter, Jan-Niklas Runge, Perran A Ross, Andrew Pomiankowski, Nicole L Nuckolls, Catherine Montchamp-Moreau, Nicole Mideo, Oliver Y Martin, Andri Manser, Mathieu Legros, Amanda M Larracuente, Luke Holman, John Godwin, Neil Gemmell, Cecile Courret, Anna Buchman, Luke G Barrett Show all

Journal of Evolutionary Biology | WILEY | Published : 2020


Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic driv..

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University of Melbourne Researchers


Awarded by Natural Environment Research Council

Awarded by National Institutes of Health, NIH

Awarded by Engineering and Physical Sciences Research Council

Awarded by Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung

Funding Acknowledgements

Steven Biggar and Elisabeth Asaro Fellowship in Data Science; Natural Environment Research Council, Grant/Award Number: NE/P002692/1 and NE/R010579/1; European Society for Evolutionary Biology; National Institutes of Health, Grant/Award Number: NIH R35GM119515; Engineering and Physical Sciences Research Council, Grant/Award Number: EP/F500351/1 and EP/I017909/1; Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung, Grant/Award Number: 31003A_160328, P300PA_177830, P300PA_177906 and ZSEZ0_180460