Journal article

Intraarterial Versus Intravenous Tirofiban as an Adjunct to Endovascular Thrombectomy for Acute Ischemic Stroke

Jianhong Yang, Yuefei Wu, Xiang Gao, Andrew Bivard, Christopher R Levi, Mark W Parsons, Longting Lin

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

BACKGROUND AND PURPOSE: This study aimed to evaluate the treatment effect of intraarterial versus intravenous tirofiban during endovascular thrombectomy in acute ischemic stroke. METHODS: This study retrospectively examined 503 patients with acute ischemic stroke with large vessel occlusion who received endovascular thrombectomy within 24 hours of stroke onset. Patients were divided into 3 groups: no tirofiban (n=354), intraarterial tirofiban (n=79), and intravenous tirofiban (n=70). The 3 groups were compared in terms of recanalization rate, symptomatic intracerebral hemorrhage, in-hospital death rate, 3-month death, and 3-month outcomes measured by modified Rankin Scale score (good clinica..

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Grants

Awarded by Ningbo Health Brand Subjecting Fund, China


Awarded by Medicine and health science and technology projects of Zhejiang province, China


Funding Acknowledgements

Dr Yang is supported by Ningbo Health Brand Subjecting Fund, China (PPXK2018-04). Y. Wu is supported by Medicine and health science and technology projects of Zhejiang province, China (2018KY687). L. Lin is funded by Science and Industry Endowment Fund on Science, Technology, Engineering and Mathematics Business Fellowship, Australia. M.W. Parsons is funded by the National Health and Medical Research Council of Australia.