Journal article

A systematic review of antiandrogens and feminization in transgender women

Lachlan M Angus, Brendan J Nolan, Jeffrey D Zajac, Ada S Cheung

Clinical Endocrinology | WILEY | Published : 2020

Abstract

Antiandrogens are frequently used with estradiol in transgender women seeking feminization. Antiandrogens act by various mechanisms to decrease the production or effects of testosterone, but it is unclear which antiandrogen is most effective at feminization. A systematic review was performed using PRISMA guidelines. We searched online databases (Medline, Embase and PsycINFO) and references of relevant articles for studies of antiandrogens in transgender women aged 16+ years to achieve feminization (namely changes in breast size, body composition, facial or body hair) or changes in serum total testosterone concentration when compared to placebo, estradiol alone or an alternative antiandrogen...

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Grants

Awarded by Australian Government National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

LMA is supported by the Research Training Program Scholarship from the Australian Commonwealth Government. BJN is supported by the Royal Australasian College of Physicians Fellows Research Entry Scholarship. ASC is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support from the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia Postdoctoral Award and the Royal Australasian College of Physicians Foundation.