Journal article

Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain

Cathryn L Ugalde, Victoria Lewis, Christiane Stehmann, Catriona A McLean, Victoria A Lawson, Steven J Collins, Andrew F Hill

BRAIN COMMUNICATIONS | OXFORD UNIV PRESS | Published : 2020

Abstract

Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a neuropathological feature of prion disorders; however, their role in the disease pathogenesis is not well understood. Here, we describe our studies of one polarization state of reactive astrocytes, termed A1 astrocytes, in the frontal cortex region of 35 human sporadic Creutzfeldt-Jakob disease brains encompassing a range of molecular sub-types. Examination of two mRNA markers of A1 astrocytes, C3 and GBP2, revealed a strong linear correlati..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by National Health and Medical Research Council Practitioner Fellowship


Funding Acknowledgements

This project was funded by the CJD Support Group Network Memorial Award 2019 in memory of Catherine and Michael Heagerty (to C.L.U.) and the National Health and Medical Research Council (NHMRC; APP1132604 to A.F.H.). S.J.C. is supported in part by a National Health and Medical Research Council Practitioner Fellowship (APP1105784).