To share or not to share data: how valid are trials evaluating first-line ovulation induction for polycystic ovary syndrome?
Esmee M Bordewijk, Rui Wang, Madelon van Wely, Michael F Costello, Robert J Norman, Helena Teede, Lyle C Gurrin, Ben W Mol, Wentao Li
Human Reproduction Update | OXFORD UNIV PRESS | Published : 2020
BACKGROUND: In our recent individual participant data (IPD) meta-analysis evaluating the effectiveness of first-line ovulation induction for polycystic ovary syndrome (PCOS), IPD were only available from 20 studies of 53 randomized controlled trials (RCTs). We noticed that the summary effect sizes of meta-analyses of RCTs without IPD sharing were different from those of RCTs with IPD sharing. Granting access to IPD for secondary analysis has implications for promoting fair and transparent conduct of RCTs. It is, however, still common for authors to choose to withhold IPD, limiting the impact of and confidence in the results of RCTs and systematic reviews based on aggregate data. OBJECTIVE AN..View full abstract