Journal article

Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and transmission settings in The Gambia

Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K Singh, James G Beeson, Kevin KA Tetteh, Immo Kleinschmidt, Umberto D'Alessandro, Chris Drakeley

BMC Medicine | BMC | Published : 2020

Abstract

BACKGROUND: As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission. Serological assays measuring malaria antibody responses offer a cost-effective detection method to supplement existing surveillance tools. METHODS: A prospective cohort study was conducted from 2013 to 2015 in 12 villages across five administrative regions in The Gambia. Serological analysis included samples from the West Coast Region at the start and end of the season (July and December 2013) and from the Upper River Region in July and December 2013 and April and December 2014. Antigen-specific antibody responses to eight Plasmodium falciparum (P. falciparum) an..

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Grants

Awarded by UK Medical Research Council (UK MRC)


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This study was funded by the UK Medical Research Council (UK MRC) through the LSHTM Doctoral Training Programme studentship received by LW (MR/J003999/1). JGB was supported by the National Health and Medical Research Council of Australia (Investigator Grant 1173046, Program Grant 1092789). Burnet Institute is supported by the NHMRC Independent Research Institute Infrastructure Support Scheme and a Victorian State Government Operational Infrastructure grant. The funders had no role in the design of the study, collection, analysis, interpretation of data, or writing of the manuscript.