Journal article
Dysregulated Lipid Metabolism Precedes Onset of Psychosis
AM Dickens, P Sen, MJ Kempton, N Barrantes-Vidal, C Iyegbe, M Nordentoft, T Pollak, A Riecher-Rössler, S Ruhrmann, G Sachs, R Bressan, MO Krebs, GP Amminger, L de Haan, M van der Gaag, LR Valmaggia, T Hyötyläinen, P McGuire, M Calem, S Tognin Show all
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2021
Abstract
Background: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. Methods: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. Results: At baseline, compared with control subjects, CHR subj..
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Awarded by European Commission
Funding Acknowledgements
This study has received funding from the European Union's Seventh Framework Programme for projects EU-GEI-European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (Grant No. HEALTH-F2-2010-241909 [to PMG, NB-V, MN, AR-R, SR, GS, RB, M-OK, GPA, LdH, and MvdG]) and METSY-Neuroimaging Platform for Characterization of Metabolic Comorbidities in Psychotic Disorders (Grant No. 602478 [to MO]). Additional support was provided by a Medical Research Council Fellowship (Grant No. MR/J008915/1 [to MJK]), Ministerio de Ciencia, Innovacion e Universidades (Grant No. PSI2017-87512-C2-1-R), and Generalitat de Catalunya (Grant No. 2017SGR1612 and ICREA Academia Award [to NB-V]).