Journal article

Effect of age and baseline ASPECTS on outcomes in large-vessel occlusion stroke: results from the HERMES collaboration

Johanna Maria Ospel, Manon Kappelhof, Nima Kashani, Bijoy K Menon, Bruce C Campbell, Luis San Roman, Andrew M Demchuk, Diederik WJ Dippel, Jeffrey L Saver, Tudor G Jovin, Peter Mitchell, Serge Bracard, Keith Muir, Phil White, Francis Guillemin, Charles BLM Majoie, Michael D Hill, Scott Brown, Mayank Goyal

JOURNAL OF NEUROINTERVENTIONAL SURGERY | BMJ PUBLISHING GROUP | Published : 2021

Abstract

BACKGROUND: Patient age and baseline Alberta Stroke Program Early CT score (ASPECTS) are both independent predictors of outcome in acute ischemic stroke patients treated with endovascular therapy (EVT). We assessed the combined effect of age and ASEPCTS on clinical outcome in acute ischemic stroke patients with LVO with and without EVT, and EVT treatment effect in different age/ASPECTS subgroups. METHODS: The HERMES collaboration pooled data of seven randomized controlled trials that tested the efficacy of EVT. Adjusted logistic regression was performed to test for multiplicative interaction of age and ASPECTS with the primary outcome (ordinal mRS) and secondary outcomes (mRS 0-2/0-1/0-3) in..

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