Hepatitis B in the Northern Territory: insights into the changing epidemiology of an ancient condition.
Ashleigh Qama, Nicole Allard, Benjamin Cowie, Joshua Davis, Jane Davies
Internal Medicine Journal | Published : 2020
BACKGROUND: Aboriginal and Torres Strait Islander people are disproportionately affected by hepatitis B virus (HBV) infection. A proposed mismatch between standard vaccines and the HBV/C4 sub-genotype prevalent in Aboriginal people in the Northern Territory (NT) may reduce vaccine effectiveness. AIMS: This study aimed to determine the HBV prevalence in the NT by Indigenous status and to explore patterns of immunity following implementation of universal vaccination, using a large longitudinal diagnostic dataset. METHODS: A retrospective analysis of all available HBV serology results in the NT from 1991 to 2011 was conducted, with HBV prevalence and vaccination status analysed according to Ind..View full abstract