Journal article

Lactoferrin Expression Is Not Associated with Late-Onset Sepsis in Very Preterm Infants

Tobias Strunk, Julie Elizabeth Hibbert, Dorota Doherty, Elizabeth Nathan, Karen Simmer, Sanjay Keshav Patole, Stephanie Trend, Peter Richmond, David Burgner, Andrew Currie

Neonatology | KARGER | Published : 2021

Abstract

BACKGROUND: Preterm infants are at a high risk of developing late-onset sepsis (LOS). Lactoferrin is one of the most abundant endogenous antimicrobial proteins expressed in breast milk, stools, and blood, and a candidate for preventive intervention. Large clinical trials have recently investigated whether enteral supplementation with bovine lactoferrin reduces LOS. AIM: To characterize lactoferrin levels in preterm infants with and without LOS during the first month of life. METHODS: Very preterm and term infants were recruited and serial biosamples collected during the first month of life. Lactoferrin levels were determined by immunoassay in cord blood and peripheral blood on days 1, 7, 14,..

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