Beneficial Effects of Vasopressin Compared With Norepinephrine on Renal Perfusion, Oxygenation, and Function in Experimental Septic Acute Kidney Injury
Nobuki Okazaki, Naoya Iguchi, Roger G Evans, Sally G Hood, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
OBJECTIVES: To compare the effects of restoring mean arterial pressure with vasopressin or norepinephrine on systemic hemodynamics, renal blood flow, intrarenal perfusion and oxygenation, and renal function in ovine septic acute kidney injury. DESIGN: Interventional Study. SETTING: Research Institute. SUBJECTS: Adult Merino ewes. INTERVENTIONS: Flow probes were implanted on the pulmonary and renal arteries (and the mesenteric artery in sheep that received vasopressin). Fiber-optic probes were implanted in the renal cortex and medulla to measure tissue perfusion and oxygen tension (PO2). Conscious sheep were administered Escherichia coli to induce septic acute kidney injury. Vasopressin (0.03..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Future Leader Fellowship by the National Heart Foundation of Australia
Supported, in part, by a grant from the National Health and Medical Research Council of Australia (GNT1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant. Supported, in part, by a Future Leader Fellowship by the National Heart Foundation of Australia (101853; to Dr. Lankadeva).Dr. May's institution received funding from National Health and Medical Research Council of Australia and National Heart Foundation of Australia. The remaining authors have disclosed that they do not have any potential conflicts of interest.