Journal article

Beneficial Effects of Vasopressin Compared With Norepinephrine on Renal Perfusion, Oxygenation, and Function in Experimental Septic Acute Kidney Injury

Nobuki Okazaki, Naoya Iguchi, Roger G Evans, Sally G Hood, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva

CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

OBJECTIVES: To compare the effects of restoring mean arterial pressure with vasopressin or norepinephrine on systemic hemodynamics, renal blood flow, intrarenal perfusion and oxygenation, and renal function in ovine septic acute kidney injury. DESIGN: Interventional Study. SETTING: Research Institute. SUBJECTS: Adult Merino ewes. INTERVENTIONS: Flow probes were implanted on the pulmonary and renal arteries (and the mesenteric artery in sheep that received vasopressin). Fiber-optic probes were implanted in the renal cortex and medulla to measure tissue perfusion and oxygen tension (PO2). Conscious sheep were administered Escherichia coli to induce septic acute kidney injury. Vasopressin (0.03..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Future Leader Fellowship by the National Heart Foundation of Australia


Funding Acknowledgements

Supported, in part, by a grant from the National Health and Medical Research Council of Australia (GNT1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant. Supported, in part, by a Future Leader Fellowship by the National Heart Foundation of Australia (101853; to Dr. Lankadeva).Dr. May's institution received funding from National Health and Medical Research Council of Australia and National Heart Foundation of Australia. The remaining authors have disclosed that they do not have any potential conflicts of interest.