Journal article

Contrasting painless and painful phenotypes of pediatric restless legs syndrome: a twin family study

David Champion, Minh Bui, Phillip Aouad, Sara Sarraf, Theresa Donnelly, Aneeka Bott, Cindy Chapman, Shuxiang Goh, Georgia Ng, Tiina Jaaniste, John Hopper

Sleep Medicine | ELSEVIER | Published : 2020


OBJECTIVE: This study was designed to investigate painless and painful subsets of pediatric restless legs syndrome (RLS) for genetic influence and for associations with iron deficiency and common pediatric pain disorders. METHODS: In a twin family study, twins (3-18 years) and their oldest siblings, mothers and fathers completed questionnaires, assessing lifetime prevalence of RLS using current criteria, as well as history of iron deficiency and pediatric pain disorders. Subsets were categorized as RLS-Painless or RLS-Painful. Within twin pair analyses were conducted to assess familial and potential genetic effects for the defined subsets. Penalized maximum likelihood logistic regression was..

View full abstract