Journal article

Kava constituents exert selective anticancer effects in oral squamous cell carcinoma cells in vitro

Antonio Celentano, Callisthenis Yiannis, Rita Paolini, Pangzhen Zhang, Camile S Farah, Nicola Cirillo, Tami Yap, Michael McCullough



Kava is a beverage made from the ground roots of the plant Piper Methysticum. Active compounds of Kava have previously been demonstrated to exert an antiproliferative effect through cell cycle arrest and promotion of apoptosis. Our aim was to investigate the in vitro effects of the main constituents derived from Kava on oral squamous cell carcinoma (OSCC) activity. Gas chromatography mass spectrometry (GCMS) was used to characterise the main constituents of two Kava preparations. Cell proliferation was assessed in two human OSCC cell lines (H400 and BICR56) and in normal oral keratinocytes (OKF6) treated with the identified Kava constituents, namely Flavokawain A (FKA), Flavokawain B (FKB), ..

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Funding Acknowledgements

This work was supported by the University of Melbourne-F.A. Kernot Research Grant. The authors would like to thank the staff at the National Herbarium of Victoria (MEL), including the digitizing officer Angharad Johnson and the manager of the herbarium specimen collection Pina Milne, who provided the image included in Figure 1.