Journal article

Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors

Zudin A Puthucheary, Jochen S Gensichen, Aylin S Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy, Konrad FR Schmidt

Critical Care (UK) | BMC | Published : 2020

Abstract

BACKGROUND: Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cited as one potential confounder. This secondary analysis aimed to (1) examine trajectories of functional recovery in critically ill patients to delineate sub-phenotypes and (2) to assess differences between these cohorts in both clinical characteristics and clinimetric properties of physical function assessment tools. METHODS: Two hundred ninety-one adult sepsis survivors were followed-up for 24 months by telephone interviews. Physical function was assessed using the Physical..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Center for Sepsis Control and Care (CSCC) at Jena University Hospital, Germany - German Federal Ministry of Education and Research


Awarded by Francis Crick Institute from the Cancer Research UK


Awarded by UK Medical Research Council


Awarded by Wellcome Trust


Funding Acknowledgements

The SMOOTH-Study was supported by the Center for Sepsis Control and Care (CSCC) at Jena University Hospital, Germany, funded by the German Federal Ministry of Education and Research (grant 01 E0 1002) and the German Sepsis Society. Open access funding provided by the Projekt DEAL. AC was supported by the Francis Crick Institute (which receives its core funding from the Cancer Research UK (FC010110), the UK Medical Research Council (FC010110) and the Wellcome Trust (FC010110)). Open access funding provided by Projekt DEAL.