Journal article

Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells

Cole Zmurchok, Jared Collette, Vijay Rajagopal, William R Holmes

BIOPHYSICAL JOURNAL | CELL PRESS | Published : 2020

Abstract

Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. Although biochemical models of adaptation have been previously proposed, here, we discuss a different mechanism based on mechanosensing, in which the interaction between biochemical signaling and cell tension facilitates adaptation. We describe and analyze a model of mechanochemical-based adaptation coupling a mechanics-based physical model of cell tension coupled with the wave-pinning reaction-diffusion model for Rac GTPase activity. The mathematical analysis of this model, simulations of a simplified one-dimensional cell geometry, and two-dimensional finite element simulations of deformi..

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University of Melbourne Researchers

Grants

Awarded by National Science Foundation, United States


Funding Acknowledgements

The authors acknowledge Christopher Bradley for helpful discussions on numerical implementation of the coupled mechanics and reaction-diffusion simulations and Andreas Buttenschon for helpful discussions of the 1D model. This work was supported by a National Science Foundation, United States, grant DMS1562078 (to W.R.H.) and a Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship Award (to C.Z.).