Incidence of hospitalization for heart failure relative to major atherosclerotic events in type 2 diabetes: A meta-analysis of cardiovascular outcomes trials

Abstract

BACKGROUND Emerging evidence points to heart failure as being a common first presentation of cardiovascular (CV) disease in type 2 diabetes. PURPOSE The purpose of this study was to determine whether hospitalization for heart failure (HHF) occurs more or less frequently than major adverse CV events (MACE) in people with type 2 diabetes. DATA SOURCES Placebo arms of CV outcomes trials in type 2 diabetes were included. STUDY SELECTION Sixteen CV outcomes trials were selected, including five dipeptidyl peptidase 4 inhibitor trials, seven glucagon-like peptide 1 receptor agonist trials, and four sodium–glucose cotransporter 2 inhibitor trials. DATA EXTRACTION We extracted incidence rates of HHF,..