Journal article
MonitoringPlasmodium falciparumandPlasmodium vivaxusing microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea
Johanna Helena Kattenberg, Zahra Razook, Raksmei Keo, Cristian Koepfli, Charlie Jennison, Dulcie Lautu-Gumal, Abebe A Fola, Maria Ome-Kaius, Celine Barnadas, Peter Siba, Ingrid Felger, James Kazura, Ivo Mueller, Leanne J Robinson, Alyssa E Barry
Molecular Ecology | WILEY | Published : 2020
DOI: 10.1111/mec.15654
Abstract
Monitoring the genetic structure of pathogen populations may be an economical and sensitive approach to quantify the impact of control on transmission dynamics, highlighting the need for a better understanding of changes in population genetic parameters as transmission declines. Here we describe the first population genetic analysis of two major human malaria parasites, Plasmodium falciparum (Pf) and Plasmodium vivax (Pv), following nationwide distribution of long-lasting insecticide-treated nets (LLINs) in Papua New Guinea (PNG). Parasite isolates from pre- (2005-2006) and post-LLIN (2010-2014) were genotyped using microsatellite markers. Despite parasite prevalence declining substantially ..
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Awarded by National Health and Medical Research Council
Awarded by Division of Intramural Research, National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
National Health and Medical Research Council, Grant/Award Number: 1010069 and 1027108; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Grant/Award Number: U19 AI089686