Journal article

Prognostic significance of postsurgery circulating tumorDNAin nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies

Jeanne Tie, Joshua D Cohen, Serigne N Lo, Yuxuan Wang, Lu Li, Michael Christie, Margaret Lee, Rachel Wong, Suzanne Kosmider, Iain Skinner, Hui Li Wong, Belinda Lee, Matthew E Burge, Desmond Yip, Christos S Karapetis, Timothy J Price, Niall C Tebbutt, Andrew M Haydon, Janine Ptak, Mary J Schaeffer Show all

International Journal of Cancer | WILEY | Published : 2020

Abstract

Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surgery. A combined analysis of data across completed studies could further our understanding of circulating tumor DNA (ctDNA) as a prognostic marker and inform future trial design. We combined individual patient data from three independent cohort studies of nonmetastatic colorectal cancer (CRC). Plasma samples were collected 4 to 10 weeks after surgery. Mutations in ctDNA were assayed using a massively parallel sequencing technique called SafeSeqS. We analyzed 485 CRC patients (230 Stage II colon, 96 Stage III colon, and 159 locally advanced rectum). ctDNA was detected..

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Grants

Awarded by Victorian Cancer Agency Clinical Research Fellowship


Awarded by National Institutes of Health


Funding Acknowledgements

This work was supported by Victorian Cancer Agency Clinical Research Fellowship (CRF14007 to JT), the National Institutes of Health (P50-CA062924, CA06973, CA176828 and CA210170), the Virginia and D.K. Ludwig Fund for Cancer Research, The Sol Goldman Sequencing Facility at Johns Hopkins and the John Templeton Foundation.