Journal article
Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies
J Tie, JD Cohen, SN Lo, Y Wang, L Li, M Christie, M Lee, R Wong, S Kosmider, I Skinner, HL Wong, B Lee, ME Burge, D Yip, CS Karapetis, TJ Price, NC Tebbutt, AM Haydon, J Ptak, MJ Schaeffer Show all
International Journal of Cancer | WILEY | Published : 2021
DOI: 10.1002/ijc.33312
Abstract
Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surgery. A combined analysis of data across completed studies could further our understanding of circulating tumor DNA (ctDNA) as a prognostic marker and inform future trial design. We combined individual patient data from three independent cohort studies of nonmetastatic colorectal cancer (CRC). Plasma samples were collected 4 to 10 weeks after surgery. Mutations in ctDNA were assayed using a massively parallel sequencing technique called SafeSeqS. We analyzed 485 CRC patients (230 Stage II colon, 96 Stage III colon, and 159 locally advanced rectum). ctDNA was detected..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by Victorian Cancer Agency Clinical Research Fellowship (CRF14007 to JT), the National Institutes of Health (P50-CA062924, CA06973, CA176828 and CA210170), the Virginia and D.K. Ludwig Fund for Cancer Research, The Sol Goldman Sequencing Facility at Johns Hopkins and the John Templeton Foundation.