Journal article

Modelling within-host macrophage dynamics in influenza virus infection

Ke Li, James M McCaw, Pengxing Cao

JOURNAL OF THEORETICAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2021

Abstract

Human respiratory disease associated with influenza virus infection is of significant public health concern. Macrophages, as part of the front line of host innate cellular defence, have been shown to play an important role in controlling viral replication. However, fatal outcomes of infection, as evidenced in patients infected with highly pathogenic viral strains, are often associated with prompt activation and excessive accumulation of macrophages. Activated macrophages can produce a large amount of pro-inflammatory cytokines, which leads to severe symptoms and at times death. However, the mechanism for rapid activation and excessive accumulation of macrophages during infection remains uncl..

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Grants

Awarded by Australian Research Council (ARC) Discovery Project


Awarded by National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy


Funding Acknowledgements

Ke Li is supported by a Melbourne Research Scholarship. This work was supported by an Australian Research Council (ARC) Discovery Project (DP170103076) and a National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (1078068).