Comorbidity of Cerebrovascular and Alzheimer's Disease in Aging
Ying Xia, Nawaf Yassi, Parnesh Raniga, Pierrick Bourgeat, Patricia Desmond, James Doecke, David Ames, Simon M Laws, Christopher Fowler, Stephanie R Rainey-Smith, Ralph Martins, Paul Maruff, Victor L Villemagne, Colin L Masters, Christopher C Rowe, Jurgen Fripp, Olivier Salvado
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2020
BACKGROUND: Cerebrovascular disease often coexists with Alzheimer's disease (AD). While both diseases share common risk factors, their interrelationship remains unclear. Increasing the understanding of how cerebrovascular changes interact with AD is essential to develop therapeutic strategies and refine biomarkers for early diagnosis. OBJECTIVE: We investigate the prevalence and risk factors for the comorbidity of amyloid-β (Aβ) and cerebrovascular disease in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing, and further examine their cross-sectional association. METHODS: A total of 598 participants (422 cognitively normal, 89 with mild cognitive impairment, 87 with AD) underw..View full abstract
The AIBL study (http://www.AIBL.csiro.au) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. Partial financial support provided by the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund (SIEF), the Dementia Collaborative Research Centres (DCRC2), the Victorian Government's Operational Infrastructure Support program, the McCusker Alzheimer's Research Foundation, the National Health and Medical Research Council (NHMRC), as well as the Cooperative Research Centre (CRC) for Mental Health. Numerous commercial interactions have supported data collection and analysis. In-kind support has also been provided by Sir Charles Gairdner Hospital, CogState Ltd., Hollywood Private Hospital, the University of Melbourne, and St Vincent's Hospital. NY is funded by a National Health and Medical Research Council -Australian Research Council Dementia Research Fellowship. SRRS is funded by a BrightFocus Foundation Fellowship.