Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila
Felipe Martelli, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusitha Rupasinghe, Kartik Venkatachalam, Trent Perry, Hugo J Bellen, Philip Batterham
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2020
Declining insect population sizes are provoking grave concern around the world as insects play essential roles in food production and ecosystems. Environmental contamination by intense insecticide usage is consistently proposed as a significant contributor, among other threats. Many studies have demonstrated impacts of low doses of insecticides on insect behavior, but have not elucidated links to insecticidal activity at the molecular and cellular levels. Here, the histological, physiological, and behavioral impacts of imidacloprid are investigated in Drosophila melanogaster, an experimental organism exposed to insecticides in the field. We show that oxidative stress is a key factor in the m..View full abstract
F.M. was supported by a Victorian Latin America Doctoral Scholarship, an Alfred Nicholas Fellowship, and a University of Melbourne Faculty of Science Travelling Scholarship. P.B. was supported by The University of Melbourne. H.J.B. was supported by the Howard Hughes Medical Institute (HHMI) and is an investigator of HHMI. K.V. was supported by an NIH (National Institute on Aging) grant. Lipid analyses were performed at Metabolomics Australia at The University of Melbourne, which is a National Collaborative Research Infrastructure Strategy Initiative under Bioplatforms Australia Proprietary Ltd. (https://bioplatforms.com/).