Journal article

The old and the new: DNA and RNA methylation in normal and malignant hematopoiesis

Andrew A Guirguis, Brian J Liddicoat, Mark A Dawson

EXPERIMENTAL HEMATOLOGY | ELSEVIER SCIENCE INC | Published : 2020

Abstract

Whilst DNA cytosine methylation is the oldest and most well-studied epigenetic modification, basking in its glory days, it may be soon overshadowed by the new kid on the block: RNA adenosine methylation. This juxtaposition is indeed superficial, and a deep exploration toward the fundamental requirements for these essential epigenetic marks provides a clear perspective on their converging and synergistic roles. The recent discovery that both of these modifications are essential for preventing inappropriate activation of the intracellular innate immune responses to endogenous transcripts has provided a lot of interest in targeting them therapeutically as a means to improve cancer immunogenicit..

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