Journal article

High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite

Pasi K Korhonen, Robin B Gasser, Guangxu Ma, Tao Wang, Andreas J Stroehlein, Neil D Young, Ching-Seng Ang, Deepani D Fernando, Hieng C Lu, Sara Taylor, Simone L Reynolds, Ehtesham Mofiz, Shivashankar H Najaraj, Harsha Gowda, Anil Madugundu, Santosh Renuse, Deborah Holt, Akhilesh Pandey, Anthony T Papenfuss, Katja Fischer

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in devel..

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Grants

Funding Acknowledgements

Support from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC) of Australia is gratefully acknowledged (K.F, R.B.G., N.D.Y. and P. K.K). K.F. held an ARC Future Fellowship followed by an NHMRC Senior Research Fellowship and. P. K.K. held an NHMRC Early Career Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.