Journal article

Domino-like transient dynamics at seizure onset in epilepsy

Jennifer Creaser, Congping Lin, Thomas Ridler, Jonathan T Brown, Wendyl D'Souza, Udaya Seneviratne, Mark Cook, John R Terry, Krasimira Tsaneva-Atanasova

PLOS Computational Biology | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

The International League Against Epilepsy (ILAE) groups seizures into "focal", "generalized" and "unknown" based on whether the seizure onset is confined to a brain region in one hemisphere, arises in several brain region simultaneously, or is not known, respectively. This separation fails to account for the rich diversity of clinically and experimentally observed spatiotemporal patterns of seizure onset and even less so for the properties of the brain networks generating them. We consider three different patterns of domino-like seizure onset in Idiopathic Generalized Epilepsy (IGE) and present a novel approach to classification of seizures. To understand how these patterns are generated on ..

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Grants

Awarded by MRC Skills Development Fellowship


Awarded by EPSRC


Awarded by Royal Society International Exchanges Award


Awarded by National foundation of Science in China (NFSC)


Funding Acknowledgements

J.C. acknowledges funding from MRC Skills Development Fellowship MR/S019499/1, https://mrc.ukri.org.J.C., J.T. and K.T-A, gratefully acknowledge the financial support of the EPSRC via grant EP/N014391/2, https://epsrc.ukri.org.J.C.and C.L. gratefully acknowledge the financial support of the EPSRC funded Institutional Sponsorship awarded by the University of Exeter. M.C. and J.R.T. acknowledge financial support from the Royal Society International Exchanges Award (grant number IE170112) https://royalsociety.org.C.L.acknowledges financial support from National foundation of Science in China http://www.nsfc.gov.cn/english/site_1/index.html (NFSC, grant No. 11701201 and NFSC, grant No. 11871061). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.