High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies
Habtamu B Beyene, Gavriel Olshansky, Adam Alexander T Smith, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Jonathan S Shaw, Eric K Moses, Dianna J Magliano, Peter J Meikle
PLoS Biology | PUBLIC LIBRARY SCIENCE | Published : 2020
Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better understanding of the age- and sex-related metabolic consequences. High-throughput lipidomic analyses of population-based cohorts offer an opportunity to identify disease-risk-associated biomarkers and to improve our understanding of lipid metabolism and biology at a population level. Here, we comprehensively examined the relationship between lipid classes/subclasses and molecular species with age, sex, and body mass index (BMI). Furthermore, we evaluated sex specificity in the association of the plasma lipidome with age and BMI. Some 747 targeted lipid measures, re..View full abstract
Awarded by National Health and Medical Research Council of Australia
This research was supported by the National Health and Medical Research Council of Australia (Project grant APP1101320). This work was also supported in part by the Victorian Government's Operational Infrastructure Support Program. JSS and DJM are supported by Senior Research Fellowships from the National Health and Medical Research Council of Australia. HBB was supported by the Baker institute and Monash University Scholarships. The 1994/95 Busselton health survey was supported by a grant from the Health Promotion Foundation of Western Australia, and the authors acknowledge the generous support for the 1994/1995 Busselton Health Study follow-up from Western Australia and the Great Wine Estates of the Margaret River region of Western Australia. Support from the Royal Perth Hospital Medical Research Foundation is also gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.