Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein)
Hann Low, Nigora Mukhamedova, Luciano dos Santos Aggum Capettini, Yining Xia, Irena Carmichael, Stephen H Cody, Kevin Huynh, Michael Ditiatkovski, Ryunosuke Ohkawa, Michael Bukrinsky, Peter J Meikle, Soo-Ho Choi, Seth Field, Yury Miller, Dmitri Sviridov
Arteriosclerosis Thrombosis and Vascular Biology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
OBJECTIVE: AIBP (apolipoprotein A-I binding protein) is an effective and selective regulator of lipid rafts modulating many metabolic pathways originating from the rafts, including inflammation. The mechanism of action was suggested to involve stimulation by AIBP of cholesterol efflux, depleting rafts of cholesterol, which is essential for lipid raft integrity. Here we describe a different mechanism contributing to the regulation of lipid rafts by AIBP. Approach and Results: We demonstrate that modulation of rafts by AIBP may not exclusively depend on the rate of cholesterol efflux or presence of the key regulator of the efflux, ABCA1 (ATP-binding cassette transporter A-I). AIBP interacted w..View full abstract
Awarded by National Institutes of Health
This study was supported by grants from the National Institutes of Health: HL131473 (to D. Sviridov), NS102432, HL135737, HL136275, NS104769 (to Y. I. Miller) and supported in part by the Victorian Government's OIS Program (D. Sviridov).