Journal article

USING MICROPERIMETRY AND LOW-LUMINANCE VISUAL ACUITY TO DETECT THE ONSET OF LATE AGE-RELATED MACULAR DEGENERATION A LEAD Study Report

Zhichao Wu, Chi D Luu, Lauren AB Hodgson, Emily Caruso, Fred K Chen, Usha Chakravarthy, Jennifer J Arnold, Wilson J Heriot, Jim Runciman, Robyn H Guymer

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

Abstract

PURPOSE: To evaluate the performance of microperimetry and low-luminance visual acuity for detecting late age-related macular degeneration (AMD) onset. METHODS: Two hundred ninety-two individuals with bilateral large drusen in the Laser Intervention in the Early Stages of AMD study underwent best-corrected visual acuity, low-luminance visual acuity, and microperimetry testing as well as multimodal imaging to detect late (neovascular or atrophic) AMD onset. The performance of the change in the measurement from baseline of each of visual function test for detecting late AMD onset was compared. RESULTS: The area under the receiver operating characteristic curve for detecting neovascular and atr..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Supported by the National Health and Medical Research Council of Australia (project grant no.: APP1027624 [R.H.G. and C.D.L.], and fellowship grant no.: GNT1103013 [R.H.G.], APP1104985 [Z.W.], APP1054712 [F.K.C.], and APP1142962 [F.K.C.]) and BUPA Health Foundation (Australia) (R.H.G. and C.D.L.). The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government. The web-based Research Electronic Data Capture (REDCap) application and open-source platform OpenClinica allowed secure electronic data capture. The study is sponsored by the Centre for Eye Research Australia (CERA), an independent medical research institute and a not-for-profit company.