Journal article

A Molecular Classification of Human Mesenchymal Stromal Cells

Florian Rohart, Elizabeth Mason, Nicholas Matigian, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Suzanne Butcher, Jatin Patel, Kerry Atkinson, Kiarash Khosrotehrani, Nicholas Fisk, Kim-Anh Lê Cao, Christine Wells

Published : 2015

Abstract

Mesenchymal stromal cells (MSC) are widely used, isolated from a variety of tissues and increasingly adopted for cell therapy, but the identity of these cells is poorly defined and commonalities between MSC from different tissues sources is controversial. Here we undertook a comprehensive review of all public MSC expression studies to assess whether cells derived from different sources shared any common molecular attributes. In doing so, we discovered an over-arching transcriptional phenotype shared by a wide variety of MSC, freshly isolated or cultured cells, and under a variety of growth conditions. We developed a modified variable selection protocol that included cross platform normalisat..

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