Journal article

Novel approaches to combat preeclampsia: from new drugs to innovative delivery

Natasha de Alwis, Natalie K Binder, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Fiona Brownfoot, Natalie J Hannan

Placenta | W B SAUNDERS CO LTD | Published : 2020

Abstract

Preeclampsia is a complex disease affecting 2-8% of pregnancies worldwide. It poses significant risk of maternal and perinatal morbidity and mortality. Despite the rising research interest to discover new therapeutic approaches to prevent and treat preeclampsia, options remain limited. Identifying the important pathological stages in the progression of this disease allows us to evaluate effective candidate therapeutics. Three important stages in the pathophysiology are: 1) placental hypoxia and oxidative stress, 2) excess release of anti-angiogenic and pro-inflammatory factors, and 3) widespread systemic endothelial dysfunction and vasoconstriction. Repurposing drugs already safe for use in ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The National Health and Medical Research Council of Australia provided salary support (TKL #1159261, ST #1136418, FB #1142636, and NJH #1146128). The funders had no role in the reveiw or decision to publish.