Journal article

Evaluation of cerebellar function scores in relation to cerebellar axonal loss in multiple sclerosis

F Boonstra, S Gajamange, G Noffs, T Perera, M Strik, A Vogel, H Butzkueven, A Evans, A van der Walt, S Kolbe

Cold Spring Harbor Laboratory

Abstract

AbstractBackgroundCerebellar damage is common in people with multiple sclerosis (pwMS) and is associated with worse progression and relapse recovery. Studies into the importance of the cerebellum in pwMS are hampered by limited understanding of cerebellar damage and its relation to cerebellar function in pwMS.ObjectiveExamine axonal loss, as a primary driver of progressive neurological decline, in the cerebellum using advanced diffusion MRI and compare axonal loss with cerebellar dysfunction in pwMSMethodsWe recruited 55 pwMS and 14 healthy controls. Clinical assessments included scale for the assessment and rating of ataxia (SARA), and Bain tremor ratings. Subjects underwent FLAIR, T1-weigh..

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University of Melbourne Researchers

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