Managing HIV-associated inflammation and ageing in the era of modern ART

Abstract

Objectives This paper aims to address the concerns around ongoing immune activation, inflammation, and resistance in those ageing with HIV that represent current challenges for clinicians. Methods Presentations at a symposium addressing issues of ageing with HIV infection were reviewed and synthesised. Results The changing natural history and demographics of human immunodeficiency virus (HIV)‐infected individuals means new challenges in contemporary management. In the early years of the epidemic,management was focussed on acute, potentially life‐threatening AIDS‐related complications. From initial monotherapy with first‐generation antiretroviral therapy (ART), the development of combinatio..