Journal article

BATF3 programs CD8( )T cell memory

Marco A Ataide, Karl Komander, Konrad Knoepper, Annika E Peters, Hao Wu, Sarah Eickhoff, Tea Gogishvili, Justus Weber, Anika Grafen, Axel Kallies, Natalio Garbi, Hermann Einsele, Michael Hudecek, Georg Gasteiger, Michael Hoelzel, Martin Vaeth, Wolfgang Kastenmueller

NATURE IMMUNOLOGY | NATURE PORTFOLIO | Published : 2020

Abstract

Antiviral CD8+ T cell responses are characterized by an initial activation/priming of T lymphocytes followed by a massive proliferation, subset differentiation, population contraction and the development of a stable memory pool. The transcription factor BATF3 has been shown to play a central role in the development of conventional dendritic cells, which in turn are critical for optimal priming of CD8+ T cells. Here we show that BATF3 was expressed transiently within the first days after T cell priming and had long-lasting T cell-intrinsic effects. T cells that lacked Batf3 showed normal expansion and differentiation, yet succumbed to an aggravated contraction and had a diminished memory resp..

View full abstract

University of Melbourne Researchers

Grants

Awarded by German Research Foundation


Awarded by German Research Foundation Emmy Noether programme


Awarded by European Research Council


Awarded by Germany's Excellence Strategy


Funding Acknowledgements

We thank the Core Unit for FACS and the Core Unit SysMed of the IZKF Wurzburg for supporting this study, H.C. Probst (Institute for Immunology, Mainz University) and T. Kaisho (Immunology Frontier Research Center, Osaka University) for providing the P14 and XCR1-DTR-Venus mice31, respectively. The B8R tetramer was obtained through the National Institutes of Health Tetramer Core Facility. This work was supported by grants through the German Research Foundation, SFB TR 221 (project A03 to M. Hudecek and H.E.), Germany's Excellence Strategy -EXC2151 -(390873048 to M. Holzel) and German Research Foundation Emmy Noether programme (GA2129/2-1 to G.G.) and by grants of the European Research Council to W.K. (819329-STEP2) and G.G. (759176-TissueLymphoContexts). W.K., G.G. and M.V. are supported by the by the Max Planck Society (Max Planck Research Groups).