Intra-cerebral haemorrhage but not neurodegenerative disease appears over-represented in deaths of Australian cadaveric pituitary hormone recipients

Sultan H Alnakhli; Handan Wand; Matthew Law; Shannon Sarros; Christiane Stehmann; Matteo Senesi; Genevieve M Klug; Marion Simpson; Victoria Lewis; Colin L Masters; Steven J Collins

Journal article

Intra-cerebral haemorrhage but not neurodegenerative disease appears over-represented in deaths of Australian cadaveric pituitary hormone recipients

Sultan H Alnakhli, Handan Wand, Matthew Law, Shannon Sarros, Christiane Stehmann, Matteo Senesi, Genevieve M Klug, Marion Simpson, Victoria Lewis, Colin L Masters, Steven J Collins

Journal of Clinical Neuroscience | ELSEVIER SCI LTD | Published : 2020

DOI: 10.1016/j.jocn.2020.09.021

Abstract

BACKGROUND AND PURPOSE: Recent scientific reports and epidemiological studies have engendered mounting concerns regarding the potential human-to-human transmissibility of non-prion neurodegenerative and related diseases. This study investigated whether recipients of cadaveric pituitary hormone treatments are at increased risk of death from non-prion neurodegenerative and related diseases. METHODS: A retrospective national cohort study based on death certificates of recipients of the cadaveric pituitary hormone treatments (n = 184) as part of the Australian Human Pituitary Hormone Program (AHPHP; n = 2940) 1967-1985. Standardised mortality ratios (SMR) from non-prion neurodegenerative and oth..

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