Peripheral and central mechanisms of cough hypersensitivity
Nabita Singh, Alexandria K Driessen, Alice E McGovern, Aung Aung Kywe Moe, Michael J Farrell, Stuart B Mazzone
JOURNAL OF THORACIC DISEASE | AME PUBL CO | Published : 2020
Chronic cough is a difficult to treat symptom of many respiratory and some non-respiratory diseases, indicating that varied pathologies can underpin the development of chronic cough. However, clinically and experimentally it has been useful to collate these different pathological processes into the single unifying concept of cough hypersensitivity. Cough hypersensitivity syndrome is reflected by troublesome cough often precipitated by levels of stimuli that ordinarily don't cause cough in healthy people, and this appears to be a hallmark feature in many patients with chronic cough. Accordingly, a strong argument has emerged that changes in the excitability and/or normal regulation of the per..View full abstract
Awarded by National Health & Medical Research Council (NHMRC) of Australia
This research was supported by grants to Dr. Mazzone and Dr. Farrell from the National Health & Medical Research Council (NHMRC) of Australia (APP1042528).