Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task
S Li, C May, AJ Hannan, KA Johnson, EL Burrows
Neuropsychopharmacology | SPRINGERNATURE | Published : 2020
Atypical attention orienting has been found to be impaired in many neuropsychological disorders, but the underlying neural mechanism remains unclear. Attention can be oriented exogenously (i.e., driven by salient stimuli) or endogenously (i.e., driven by one's goals or intentions). Genetic mouse models are useful tools to investigate the neurobiology of cognition, but a well-established assessment of attention orienting in mice is missing. This study aimed to adapt the Posner task, a widely used attention orienting task in humans, for use in mice using touchscreen technology and to test the effects of two attention-modulating drugs, methylphenidate (MPH) and atomoxetine (ATX), on the perform..View full abstract
Awarded by National Health and Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship
Awarded by NHMRC Principal Research Fellowship
SL is supported by the Melbourne Research Scholarship, a graduate research scholarship established by the University of Melbourne. ELB is supported by a National Health and Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship (1111552). AJH is supported by an NHMRC Principal Research Fellowship (1117148). The authors declare no competing interests.