SPARC: Noise Analysis and Signal Drift Correction in Long-Period Multi-Unit Recordings of Action Potentials in Autonomic Nerves

Abstract

Recordings of spike activity in small peripheral autonomic nerves close to organs can provide real‐time information about the functional states of those organs (afferent traffic) and the neural systems that control them (efferent traffic). However, maintaining long‐term multifiber recordings from autonomic nerves in vivo poses significant and unique technical challenges. Many visceral nerves consist almost entirely of C fiber axons in which action potentials produce very small currents with little spatial segregation, making individual units difficult to distinguish based on spike shape in multifiber filaments recorded conventionally under mineral ..