Superinfection and recombination of infectious laryngotracheitis virus vaccines in the natural host
Omid Fakhri, Joanne M Devlin, Glenn F Browning, Mauricio JC Coppo, Jose A Quinteros, Andres Diaz-Mendez, Sang-Won Lee, Carol A Hartley
Vaccine | Elsevier | Published : 2020
Infectious laryngotracheitis virus (ILTV, Gallid alphaherpesvirus 1) causes severe respiratory disease in chickens and has a major impact on the poultry industry worldwide. Live attenuated vaccines are widely available and are administered early in the life of commercial birds, often followed by one or more rounds of revaccination, generating conditions that can favour recombination between vaccines. Better understanding of the factors that contribute to the generation of recombinant ILTVs will inform the safer use of live attenuated herpesvirus vaccines. This study aimed to examine the parameters of infection that allow superinfection and may enable the generation of recombinant progeny in ..View full abstract
SWL was funded by an Australian Research Council Discovery Early Career Researcher award. OF was supported by a Melbourne International Research Scholarship from The University of Melbourne.