Journal article
Health and fertility of ICSI-conceived young men: Study protocol
SR Catford, S Lewis, J Halliday, J Kennedy, MK O'Bryan, J McBain, DJ Amor, L Rombauts, R Saffery, RJ Hart, RI McLachlan
Human Reproduction Open | OXFORD UNIV PRESS | Published : 2020
Open access
Abstract
STUDY QUESTIONS: What are the long-term health and reproductive outcomes for young men conceived using ICSI whose fathers had spermatogenic failure (STF)? Are there epigenetic consequences of ICSI conception? WHAT IS KNOWN ALREADY: Currently, little is known about the health of ICSI-conceived adults, and in particular the health and reproductive potential of ICSI-conceived men whose fathers had STF. Only one group to date has assessed semen parameters and reproductive hormones in ICSI-conceived men and suggested higher rates of impaired semen quality compared to spontaneously conceived (SC) peers. Metabolic parameters in this same cohort of men were mostly comparable. No study has yet evalua..
View full abstractGrants
Awarded by National Health and Medical Research Council
Awarded by NHMRC
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
National Health and Medical Research Council (APP1140706). Partners include the Murdoch Children's Research Institute, Hudson Institute of Medical Research, Monash University, Monash Health, Victorian Assisted Reproductive Treatment Authority (VARTA), Monash IVF Group, Melbourne IVF, Fertility Society of Australia and ACCESS Australia. This study also received partial funding from the Monash IVF Research and Education Foundation. S.R.C. is supported through an Australian Government Research Training Program Scholarship. M.K.O. is supported by the NHMRC as a Principal Research Fellow (fellowship number: 1058356), R.J.H. is supported by an NHMRC project grant (634457), and J.H. and R.I.M. have been supported by the NHMRC as Senior and Principal Research Fellows, respectively (fellowship numbers: 1021252 to J.H., 1022327 to R.I.M.).