Immune recognition of phosphoantigen-butyrophilin molecular complexes by γδ T cells

AP Uldrich; M Rigau; DI Godfrey

Journal article

Immune recognition of phosphoantigen-butyrophilin molecular complexes by γδ T cells

AP Uldrich, M Rigau, DI Godfrey

Immunological Reviews | WILEY | Published : 2020

DOI: 10.1111/imr.12923

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Abstract

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhibit diverse functional attributes including rapid activation, cytokine production, proliferation, and acquisition of cytotoxicity following both TCR-dependent and TCR-independent stimulation, but poor capacity for immunological memory. They can detect a broad range of antigens, although typically not peptide-MHC complexes in contrast to alpha-beta (αβ) T cells. In humans, a prominent population of γδ T cells, defined as Vγ9Vδ2+ cells, reacts to small phosphorylated non-peptide “phosphoantigens” (pAgs). The molecular mechanism underpinning this recognition is poorl..

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University of Melbourne Researchers

Adam Uldrich Author

Marc Rigau Cortal Author

Dale Godfrey Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

Cancer Council of Victoria, Grant/Award Number: 1126866; Australian Research Council (ARC), Grant/Award Number: CE140100011 and DP170102471; National Health and Medical Research Council of Australia (NHMRC), Grant/Award Number: 1184906, 1165467 and 1113293; ARC Future Fellowship, Grant/Award Number: FT140100278; Deutsche Forschungsgemeinschaft, Grant/Award Number: GRK2168; University of Melbourne through the International Research and Research Training Fund; NHMRC Senior Principal Research Fellowship, Grant/Award Number: 1117766