Journal article

Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

IMMUNOLOGICAL REVIEWS | WILEY | Published : 2020

Abstract

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhibit diverse functional attributes including rapid activation, cytokine production, proliferation, and acquisition of cytotoxicity following both TCR-dependent and TCR-independent stimulation, but poor capacity for immunological memory. They can detect a broad range of antigens, although typically not peptide-MHC complexes in contrast to alpha-beta (αβ) T cells. In humans, a prominent population of γδ T cells, defined as Vγ9Vδ2+ cells, reacts to small phosphorylated non-peptide "phosphoantigens" (pAgs). The molecular mechanism underpinning this recognition is poorl..

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Grants

Awarded by Cancer Council of Victoria


Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by ARC Future Fellowship


Awarded by Deutsche Forschungsgemeinschaft


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

Cancer Council of Victoria, Grant/Award Number: 1126866; Australian Research Council (ARC), Grant/Award Number: CE140100011 and DP170102471; National Health and Medical Research Council of Australia (NHMRC), Grant/Award Number: 1184906, 1165467 and 1113293; ARC Future Fellowship, Grant/Award Number: FT140100278; Deutsche Forschungsgemeinschaft, Grant/Award Number: GRK2168; University of Melbourne through the International Research and Research Training Fund; NHMRC Senior Principal Research Fellowship, Grant/Award Number: 1117766