Determining Maximal Tolerable Aerobic Training Intensity in the Acute Phase after Stroke: a Novel Dose Ranging Trial Protocol
Sharon F Kramer, Toby Cumming, Liam Johnson, Leonid Churilov, Julie Bernhardt
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | ELSEVIER | Published : 2020
INTRODUCTION: There is strong evidence that cardiorespiratory fitness (CRF) training improves fitness and mobility after stroke. Despite the large number of studies, the most efficacious dose is yet to be determined. Furthermore, the safety of early post-stroke training, while theoretically beneficial, remains uncertain. The aim of this study is to determine the maximum safe and tolerable intensity of CRF training early post-stroke. METHODS: This is a stratified (low to moderate exercise capacity), Phase I, 5+5 dose ranging trial protocol. Participants will be recruited within one month post-stroke and stratified by their exercise-capacity (i.e. low and moderate capacity). Cohorts of five pa..View full abstract
Awarded by NHMRC
Awarded by NHMRC Centre of Research Excellence in Stroke Recovery and Brain Rehabilitation
Awarded by Austin Medical Research Foundation
SK received an Australian Postgraduate Award by the Australian Government (2014-2018). Research Foundation grant. JB is supported by a NHMRC Principle Research Fellowship (#1154904). The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular funding from the Operational Infrastructure Support Grant. The project has received funding from the NHMRC Centre of Research Excellence in Stroke Recovery and Brain Rehabilitation (#1077898) and the Austin Medical Research Foundation (#2-1326).