Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia
Danielle J Ingle, Patiyan Andersson, Mary Valcanis, Jessica Barnden, Anders Goncalves da Silva, Kristy A Horan, Torsten Seemann, Marion Easton, Deborah A Williamson, Norelle L Sherry, Benjamin P Howden
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2020
In Australia, cases of shigellosis usually occur in returned travelers from regions of shigellosis endemicity or in men who have sex with men. Resistance to multiple antibiotics has significantly increased in Shigella sonnei isolates and represents a significant public health concern. We investigate an outbreak of multidrug-resistant S. sonnei in Victoria, Australia. We undertook whole-genome sequencing of 54 extended-spectrum-beta-lactamase (ESBL)-producing S. sonnei isolates received at the Microbiological Diagnostic Unit Public Health Laboratory between January 2019 and March 2020. The population structure and antimicrobial resistance profiles were identified by genomic analyses, with 73 ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) Australia
Awarded by NHMRC
This work was supported by a National Health and Medical Research Council (NHMRC) Australia partnership grant (APP1149991). B.P.H. was supported by an NHMRC practitioner fellowship (APP1105905). The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Victorian Government.