Journal article

Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties

Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor, Jerome Sarris

Journal of Translational Medicine | BMC | Published : 2020


BACKGROUND: Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (THC) has been associated with an anxiogenic response, while anxiolytic activity has been attributed mainly to cannabidiol (CBD). In animal studies, the effects of THC are highly dose-dependent, and biphasic effects of cannabinoids on anxiety-related responses have been extensively documented. A more precise assessment is required of both the anxiolytic and anxiogenic potentials of phytocannabinoids, with an aim towards the development of the 'holy grail' in cannabis researc..

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University of Melbourne Researchers