Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties
Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor, Jerome Sarris
Journal of Translational Medicine | BMC | Published : 2020
BACKGROUND: Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (THC) has been associated with an anxiogenic response, while anxiolytic activity has been attributed mainly to cannabidiol (CBD). In animal studies, the effects of THC are highly dose-dependent, and biphasic effects of cannabinoids on anxiety-related responses have been extensively documented. A more precise assessment is required of both the anxiolytic and anxiogenic potentials of phytocannabinoids, with an aim towards the development of the 'holy grail' in cannabis researc..View full abstract
Awarded by NHMRC Clinical Research Fellowship
J.Sarris is supported by an NHMRC Clinical Research Fellowship (APP112500).