Topographic organization of the human subcortex unveiled with functional connectivity gradients
Ye Tian, Daniel S Margulies, Michael Breakspear, Andrew Zalesky
NATURE NEUROSCIENCE | NATURE RESEARCH | Published : 2020
Brain atlases are fundamental to understanding the topographic organization of the human brain, yet many contemporary human atlases cover only the cerebral cortex, leaving the subcortex a terra incognita. We use functional MRI (fMRI) to map the complex topographic organization of the human subcortex, revealing large-scale connectivity gradients and new areal boundaries. We unveil four scales of subcortical organization that recapitulate well-known anatomical nuclei at the coarsest scale and delineate 27 new bilateral regions at the finest. Ultrahigh field strength fMRI corroborates and extends this organizational structure, enabling the delineation of finer subdivisions of the hippocampus an..View full abstract
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Awarded by National Institutes of Health (NIH)
Awarded by NHMRC
We thank M. Glasser (Washington University) for provision of the Wishart filter code. We thank L. Cocchi (QIMR Berghofer Medical Research Institute) for provision of the additional validation dataset. All other data were provided by the HCP, the WU-Minn Consortium (1U54MH091657; Principal Investigators: D. Van Essen and K. Ugurbil) funded by the 16 National Institutes of Health (NIH) institutes and centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. Y.T. was supported by a NHMRC Project Grant awarded to A.Z. (APP1142801). M.B. and A.Z. were each supported by research fellowships from the NHMRC (APP1136649 and APP1118153, respectively).